Status:
COMPLETED
Effect of Intravenous Ceftriaxone and Oral Doxycycline for Lyme Neuroborreliosis
Lead Sponsor:
Sorlandet Hospital HF
Conditions:
Lyme Neuroborreliosis
Eligibility:
All Genders
18-100 years
Phase:
PHASE3
Brief Summary
The aim of this study is to compare parenteral ceftriaxone and oral doxycycline in the treatment of neuroborreliosis in a randomized controlled trial.
Eligibility Criteria
Inclusion
- Neurological symptoms and/or findings consistent with neuroborreliosis and at least one of the following fulfilled:
- Intrathecal production of borrelia antibodies;
- White cell count in cerebrospinal fluid (CSF) \> 5/mm3;
- Significant rise in borrelia antibodies in two serum samples collected from a patient with at least 3 weeks interval;
- Verified acrodermatitis chronica atrophicans.
Exclusion
- Allergy to the contents in the medication, or earlier type I reaction to penicillin.
- Treatment with cephalosporins, penicillin or tetracyclins during the last 14 days
- Pregnancy or breastfeeding
- Age \< 18 years
Key Trial Info
Start Date :
March 1 2004
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2008
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT00138801
Start Date
March 1 2004
End Date
December 1 2008
Last Update
May 6 2023
Active Locations (1)
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1
Sørlandet Sykehus HF
Kristiansand, Vest-Agder, Norway, 4633