Status:
COMPLETED
Citrulline: A Plasmatic Marker to Assess and Monitor Small Bowel Crohn's Disease Patients
Lead Sponsor:
St Mark's Hospital Foundation
Conditions:
Crohn's Disease
Short Bowel Syndrome
Eligibility:
All Genders
18-80 years
Brief Summary
Citrulline is an amino acid produced in the intestine and in the liver, but the liver does not contribute significantly to circulating citrulline concentrations. The intestine is thus the only organ t...
Detailed Description
Preliminary studies reported that plasma citrulline concentrations may be a reliable biochemical marker for intestinal dysfunction and absorptive enterocyte mass. The relationship between citrulline c...
Eligibility Criteria
Inclusion
- Crohn's disease (CD) with massive small bowel resection at least 24 months previously (\< 50cm remaining)
- Crohn's disease with small bowel resection at least 24 months previously (50-150cm remaining)
- CD with no resection
- Mesenteric infarction with massive resection \> 24 months previously (\< 50cm remaining)
- Mesenteric infarction with massive resection \> 24 months previously (50-150cm remaining); coeliac disease.
- Healthy volunteers.
- Body mass index within the normal range
Exclusion
- Patients with surgical resection of stomach, duodenum or pancreas; or upper gastrointestinal (UGI) bypass.
- Oral feeding \> 1.0-fold the estimated basal metabolic rate as assessed using Harris and Benedict equations.
- Patients with fistulating Crohn's disease
- Patients on steroids
- Patients with other important disease, which may interfere with the study (especially diabetes and renal impairment). Alcoholism, drug abuse or any other circumstances, which may compromise the patient's ability to comply with the study requirements.
- Pregnancy.
- Corticosteroid use or octreotide during, or in, the month before the study.
- Use of glucagon-like peptide 2 (GLP2), growth hormone (GH) or glutamine or triglycerides.
Key Trial Info
Start Date :
May 1 2003
Trial Type :
OBSERVATIONAL
End Date :
June 1 2005
Estimated Enrollment :
54 Patients enrolled
Trial Details
Trial ID
NCT00138879
Start Date
May 1 2003
End Date
June 1 2005
Last Update
December 15 2005
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
St Mark's Hospital
London, Middlesex, United Kingdom, HA1 3JX