Status:
COMPLETED
Efficacy of Sulphadoxine-pyrimethamine and Artemisinin-containing Combination Therapy for Malaria
Lead Sponsor:
Centers for Disease Control and Prevention
Collaborating Sponsors:
United States Agency for International Development (USAID)
Conditions:
Malaria (Uncomplicated)
Eligibility:
All Genders
Phase:
PHASE4
Brief Summary
This is an ongoing monitoring activity of efficacy of sulfadoxine-pyrimethamine (SP), which is the current national treatment of choice for uncomplicated malaria in Tanzania, and a combination of SP a...
Detailed Description
This is an ongoing monitoring activity of efficacy of sulfadoxine-pyrimethamine (SP), which is the current national treatment of choice for uncomplicated malaria in Tanzania, and a combination of SP a...
Eligibility Criteria
Inclusion
- Children \< 5 years of age (in one site, patients of all ages are eligible).
- Documented fever (axillary temperature \>= 37.5oC) in the absence of another obvious cause of fever or other serious or chronic medical condition
- Unmixed infection with P. falciparum of between 2,000 and 250,000 asexual parasites/mm3
- Patients' or the patients' parent's or guardian's informed consent and willingness to participate in the study
Exclusion
- Any evidence of severe malaria that would require hospitalization for treatment.
- Reported allergy to any antimalarial drugs, including sulfa and artemisinin drugs.
- History of pregnancy or delayed menstrual period
- Breastfeeding a child less than 8 weeks of age
Key Trial Info
Start Date :
January 1 2000
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2008
Estimated Enrollment :
390 Patients enrolled
Trial Details
Trial ID
NCT00140361
Start Date
January 1 2000
End Date
January 1 2008
Last Update
September 11 2012
Active Locations (3)
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1
Ngere Ngere Health Center
Ngerengere, Morogoro Rural, Tanzania
2
Ikwiriri Health Center
Ikwiriri, Rufiji, Tanzania
3
Lupiro Health Center
Lupiro, Ulanga, Tanzania