Status:
COMPLETED
Neuroendocrine Modulation of Metabolic Effects in Overweight Adolescents
Lead Sponsor:
Massachusetts General Hospital
Conditions:
Obesity
Eligibility:
FEMALE
12-18 years
Brief Summary
This study will examine hormonal differences in ghrelin and growth hormone in obese and normal weight adolescents and their relationship to body composition and insulin resistance. The study will also...
Detailed Description
Obesity is an epidemic that is striking people at younger ages than ever before. Obesity is associated with changes in the secretory patterns of several hormones including ghrelin, growth hormone (GH)...
Eligibility Criteria
Inclusion
- Girls 12-18 years of age
- Obese subjects: BMI higher than the 95th percentile for age and sex
- Normal-weight controls: BMI from the 15th to the 85th percentiles for age and sex
Exclusion
- History of disorders other than obesity that may affect growth hormone, ghrelin, cortisol, or insulin secretion such as eating disorder, diabetes mellitus, hypertension, thyroid disease, Cushing's syndrome, liver disease, renal failure, or an excess or deficiency of GH or cortisol
- Medications that could affect glucose and lipid levels or the secretion of growth hormone, ghrelin, insulin, or cortisol such as rhGH, glucocorticoids, and birth control pills
- Pregnancy
- Smoking or substance abuse
- Active dieting
- Surgical procedures for obesity
- Dietary restrictions such as bread, dairy, peanut, aspartame, or meat products used in the study
- Metal implants, including intracranial surgical clips or pacemakers
Key Trial Info
Start Date :
May 1 2005
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
June 1 2007
Estimated Enrollment :
47 Patients enrolled
Trial Details
Trial ID
NCT00140842
Start Date
May 1 2005
End Date
June 1 2007
Last Update
November 2 2021
Active Locations (1)
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1
Massachusetts General Hospital
Boston, Massachusetts, United States, 02114