Status:
TERMINATED
Functional Characterization of Parkin + Patients
Lead Sponsor:
Institut National de la Santé Et de la Recherche Médicale, France
Collaborating Sponsors:
Assistance Publique - Hôpitaux de Paris
Conditions:
Parkinson's Disease
Eligibility:
All Genders
18-80 years
Brief Summary
Parkinson's disease is one of the most frequent neurodegenerative diseases, and for which the mechanisms remains unknown. Since the implication of susceptibility factors is highly suspect, we have rec...
Eligibility Criteria
Inclusion
- \- Age at onset before 45 Presence of at least two of the three cardinal signs: bradykinesia, rigidity with dental wheel, postural tremor Frank response to L-Dopa (\> 30 %) Absence of personal history of meningitis-encephalopathy, neuroleptic treatment, absence of pyramidal, cerebellar or oculomotor signs, absence of dysautonomia or dementia that occurred less than 2 years before the onset of the disease Exclusion of Wilson's disease by usual biological tests Normal cerebral MRI
Exclusion
- \- Incapacity of the patient to understand and participate in the protocol
- Patients who present a contraindication to the realization of cerebral MRI (pacemaker, cardiac valve, ustensile of neurosurgery or vascular surgery, intraocular tissue) could not be included in the group of patients with PET.
- Women in age to procreate could not participate to the study with PET, only if she uses an effective contraception (oestroprogestives or a coil). Furthermore, the dates of PET examinations should be at the beginning of the menstrual cycle. At the first doubt, a dosage of b-HCG will be performed.
Key Trial Info
Start Date :
November 1 2003
Trial Type :
OBSERVATIONAL
End Date :
September 1 2006
Estimated Enrollment :
97 Patients enrolled
Trial Details
Trial ID
NCT00142311
Start Date
November 1 2003
End Date
September 1 2006
Last Update
April 19 2007
Active Locations (14)
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1
Centre Hospitalier du Pays d'Aix
Aix-en-Provence, France, 13616
2
Hôpital Gabriel Montpied
Clermont-Ferrand, France, 63000
3
CHU
Grenoble, France, 38000
4
Hôpital Roger Salengro
Lille, France, 59000