Status:
COMPLETED
Pneumonia Vaccine in Bone Marrow Transplant Recipients: Usefulness of Donor Vaccination
Lead Sponsor:
University Health Network, Toronto
Collaborating Sponsors:
The Physicians' Services Incorporated Foundation
Conditions:
Bone Marrow Transplant
Eligibility:
All Genders
16+ years
Phase:
PHASE4
Brief Summary
Streptococcus pneumoniae, also known as Pneumococcus, is a common cause of pneumonia in transplant patients. There has been a vaccine available for this infection called Pneumovax. Recently, a new vac...
Detailed Description
This is a randomized controlled trial designed to assess the immunogenicity of the new pneumococcal conjugate vaccine in a cohort of allogeneic hematopoietic stem cell transplant (allo-HSCT) recipient...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- Recipient - Adult male or female marrow recipients who fulfill the following criteria will be eligible for the study: a) Will undergo allogeneic-HSCT in 2-3 weeks.
- b) No splenectomy c) Not currently receiving IVIG d) Able to provide written informed consent and comply with study protocol e) Age \> 16
- Donor - Adult male or female marrow donors who fulfill the following criteria will be eligible for the study:
- Recipient of donor marrow agrees to participate in study.
- No prior pneumococcal vaccination within the last 5 years
- Not on immunosuppressive medication (eg., corticosteroids)
- No history of immunosuppressive condition that may potentially impair vaccine response eg, systemic lupus erythematosus, sarcoidosis, rheumatoid arthritis
- No splenectomy
- Able to provide written informed consent and comply with study protocol
- Age \> 16
Exclusion
Key Trial Info
Start Date :
May 1 2002
Trial Type :
INTERVENTIONAL
End Date :
July 1 2006
Estimated Enrollment :
70 Patients enrolled
Trial Details
Trial ID
NCT00143780
Start Date
May 1 2002
End Date
July 1 2006
Last Update
April 16 2008
Active Locations (1)
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1
University Health Network-Princess Margaret Hospital
Toronto, Ontario, Canada, M5G 2M9