Status:
COMPLETED
In-Vivo Response of P. Falciparum to Antimalarial Treatment in HIV-Infected and HIV-Uninfected Adults
Lead Sponsor:
Centers for Disease Control and Prevention
Collaborating Sponsors:
Kenya Medical Research Institute
Conditions:
Malaria
HIV
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
Plasmodium falciparum malaria and HIV are among the most important infectious diseases in sub-Saharan Africa. Approximately two-thirds of the estimated 35 million HIV infected persons live in sub-Saha...
Detailed Description
The study was conducted at Siaya District Hospital, in Nyanza Province, Kenya. Non-pregnant adults who provided consent to participate, who were found to have pure Plasmodium falciparum malaria parasi...
Eligibility Criteria
Inclusion
- 18 years of age or older, not pregnant. Are able to make all follow-up visits. Are able to understand and give informed consent. Have a history of fever in past 24hrs or current axillary temperature of ³ 37.5C.
- Have an unmixed infection with P. falciparum of at least 500 asexual parasites/mm3 as determined by microscopic examination of thick and/or thin peripheral blood smears.
- Do not have any evidence of severe or complicated malaria (e.g., cerebral malaria, Hb \< 5 g/dL, signs and symptoms of congestive heart failure) that would require hospitalisation for treatment.
- Have no reported allergy to sulfa drugs. Agree to HIV testing and receiving the results.
Exclusion
- Less than 18 yrs old. Pregnant. History of allergic reactions to sulfa drugs. Have severe or complicated malaria. No history of fever. Plan to leave Siaya in next month. Do not agree to HIV testing.
Key Trial Info
Start Date :
September 1 2002
Trial Type :
INTERVENTIONAL
End Date :
July 1 2004
Estimated Enrollment :
540 Patients enrolled
Trial Details
Trial ID
NCT00144352
Start Date
September 1 2002
End Date
July 1 2004
Last Update
September 5 2005
Active Locations (1)
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1
CDC KEMRI Research Institute
Kisumu, Kenya