Status:
COMPLETED
Comparison of Tazarotene and Minocycline Therapies for Maintenance of Facial Acne Vulgaris
Lead Sponsor:
KGL, Inc.
Collaborating Sponsors:
Milton S. Hershey Medical Center
State University of New York - Downstate Medical Center
Conditions:
Acne Vulgaris
Eligibility:
All Genders
12+ years
Phase:
PHASE4
Brief Summary
The purpose of the study is to compare the efficacy of three maintenance regimens (topical tazarotene, oral minocycline, or both) in sustaining improvement in acne.
Detailed Description
For many years antibiotic therapy has been the backbone of therapy for inflammatory acne. However, topical retinoids also offer efficacy against inflammatory acne and the combination of a topical reti...
Eligibility Criteria
Inclusion
- Moderate facial acne vulgaris 25-60 facial inflammatory acne lesions 10-100 facial comedos No more than 2 facial nodular cystic lesions (no more than 5 mm in diameter) For females of child bearing potential, a regular menstrual cycle Negative urine pregnancy test
Exclusion
- Uncontrolled systemic disease Acne vulgaris known to be resistant to antibiotics For females: pregnancy, breastfeeding, or planning pregnancy Use of estrogens or birth control pills for 12 weeks or less Any skin disease that may interfere with diagnosis or evaluation of acne vulgaris Known hypersensivity to any components in Tazarac gel or to any tetracyclines Use of any systemic retinoids in past 2 years Use of any systemic antibiotics, or participation in another drug or investigational study, in past 30 days Use of topical anti-acne medication in past 14 days
Key Trial Info
Start Date :
March 1 2002
Trial Type :
INTERVENTIONAL
End Date :
August 1 2002
Estimated Enrollment :
189 Patients enrolled
Trial Details
Trial ID
NCT00145106
Start Date
March 1 2002
End Date
August 1 2002
Last Update
December 15 2005
Active Locations (1)
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1
KGL, Inc
Broomall, Pennsylvania, United States, 19008