Status:
UNKNOWN
Identification of the Genetic Variants Responsible for Primary Biliary Cirrhosis (PBC)
Lead Sponsor:
University Health Network, Toronto
Conditions:
Liver Cirrhosis, Biliary
Biliary Cirrhosis, Primary
Eligibility:
All Genders
18-85 years
Brief Summary
Primary biliary cirrhosis (PBC) is a disease of the liver, which predominantly affects women. It causes slowly progressive liver disease, which eventually causes liver failure, requiring a liver trans...
Detailed Description
Very recently, a single nucleotide polymorphism (SNP) in the PTPN22 gene encoding the Lyp (lymphoid-specific phosphatase) PTP has been shown to be associated with susceptibility to rheumatoid arthriti...
Eligibility Criteria
Inclusion
- patients attending Liver Clinic at Toronto Western Hospital, Toronto, ON, Canada
- AMA positive and liver biopsy proven PBC.
Exclusion
- \- AMA negative PBC
Key Trial Info
Start Date :
August 1 2004
Trial Type :
OBSERVATIONAL
End Date :
Estimated Enrollment :
500 Patients enrolled
Trial Details
Trial ID
NCT00145964
Start Date
August 1 2004
Last Update
November 29 2005
Active Locations (1)
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1
Liver Clinic, Toronto Western Hospital, UHN.
Toronto, Ontario, Canada, M5T 2S8