Status:
TERMINATED
Genetic Study of Nephrolithiasis in Gouty Diathesis
Lead Sponsor:
Mario Negri Institute for Pharmacological Research
Conditions:
Nephrolithiasis
Eligibility:
All Genders
10-85 years
Brief Summary
Gouty diathesis describes uric acid or calcium oxalate nephrolithiasis and low urinary pH (\<5.5). A hereditary component has been outlined for several forms of nephrolithiasis (such as hypercalciuria...
Detailed Description
INTRODUCTION Nephrolithiasis is a common disorder with a reported incidence of 12% in industrialized countries. The peak incidence is in ages 20s to 40s. Men are affected two to three times more often...
Eligibility Criteria
Inclusion
- male and female, ≥ 10 years of age
- uric acid or calcium oxalate nephrolithiasis
- urinary 24 h pH \< 5.5 in absence of high animal protein intake (urinary sulphate excretion \<25 mM/24 h after one week of low animal protein intake)
- familial history of kidney stones (at least two first or second degree family members affected)
- written informed consent according to the Declaration of Helsinki guidelines
Exclusion
- renal colic in the 4 weeks preceding evaluations
- excessive gastrointestinal alkali loses
- inability to fully understand the purposes of the study or to provide a written informed consent
Key Trial Info
Start Date :
May 1 2005
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
May 1 2010
Estimated Enrollment :
37 Patients enrolled
Trial Details
Trial ID
NCT00149305
Start Date
May 1 2005
End Date
May 1 2010
Last Update
April 4 2023
Active Locations (1)
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1
Clinical Research Center for Rare Diseases
Ranica, Bergamo, Italy, 24020