Status:
UNKNOWN
The Viability-Guided Angioplasty After Acute Myocardial Infarction-Trial (The VIAMI-Trial)
Lead Sponsor:
Netherlands Heart Foundation
Collaborating Sponsors:
The Interuniversity Cardiology Institute of the Netherlands
Eli Lilly and Company
Conditions:
Myocardial Infarction
Coronary Artery Disease
Eligibility:
All Genders
18-80 years
Phase:
NA
Brief Summary
The VIAMI-trial investigates the effects of balloon angioplasty with stenting of the infarct-vessel in the early phase after acute myocardial infarction. The study concerns patients who have residual ...
Detailed Description
Earlier studies have shown that routine angioplasty of the infarct-related coronary artery soon after thrombolysis for acute myocardial infarction did not result in a clinical benefit. This finding em...
Eligibility Criteria
Inclusion
- Admission within 6 hours of pain onset and EKG with ≥ 1 mm ST-segment elevation in two or more standard leads or ≥ 2 mm ST-elevation in two contiguous chest leads, indicative for transmural ischemia, with or without the development of new Q-waves, with myocardial necrosis proven by enzyme rise (total CPK ≥ 2x the upper normal limit).
- Patient history compatible with subacute myocardial infarction ( ≥ 6 hours), with at least signs of myocardial necrosis on the EKG (Q-waves) and a significantly increased serum level of cardiac-specific enzymes.
- Age between 18 and 80 years.
- Viability testing performed prior to coronary angiography.
- No clinical indication for an invasive procedure to be performed before viability testing
Exclusion
- No informed consent obtained
- Unreliable follow-up
- Viability testing technically not possible
- Contra-indications for dobutamine echocardiography (heart failure, arrhythmia)
- Contra-indications for coronary angiography, such as severe diabetic nephropathy or know contrast-allergy
- Known hypersensitivity for abciximab
- Serious, life-threatening non-cardiac illness
Key Trial Info
Start Date :
April 1 2001
Trial Type :
INTERVENTIONAL
End Date :
January 1 2007
Estimated Enrollment :
300 Patients enrolled
Trial Details
Trial ID
NCT00149591
Start Date
April 1 2001
End Date
January 1 2007
Last Update
September 5 2008
Active Locations (12)
Enter a location and click search to find clinical trials sorted by distance.
1
Medical Center Alkmaar (MCA)
Alkmaar, Netherlands, 1815 JD
2
Sint LucasAndreas Hospital
Amsterdam, Netherlands, 1058 NR
3
VU University medical center
Amsterdam, Netherlands, 1081 HV
4
Catharina Hospital
Eindhoven, Netherlands, 5623 EJ