Status:
TERMINATED
Anterior Pituitary Function in Patients With Hydrocephalus
Lead Sponsor:
Johns Hopkins University
Collaborating Sponsors:
Eli Lilly and Company
Conditions:
Normal Pressure Hydrocephalus
Eligibility:
All Genders
18-80 years
Phase:
NA
Brief Summary
Hydrocephalus (secondary or idiopathic) is a condition characterized by dilatation of the lateral and third ventricles, and often associated with increased intracranial pressure (ICP). We hypothesize ...
Detailed Description
The Johns Hopkins Adult Hydrocephalus Program evaluates approximately 250 new patients per year for hydrocephalus and associated disorders, resulting in the new diagnosis of hydrocephalus in about 100...
Eligibility Criteria
Inclusion
- Diagnosis of idiopathic hydrocephalus, made by clinical and CT or MRI imaging demonstrating ventricular dilation, and confirmed by an established protocol of continuous CSF drainage via spinal catheter. Patients who are found to be eligible for VP shunt insertion on the basis of improvement in cognition/psychomotor speed, gait, or urinary continence are referred for surgery
Exclusion
- Known peripheral gland failure (primary hypogonadism, primary adrenal insufficiency, primary hypothyroidism); known history of pituitary tumor, pituitary surgery, pituitary hemorrhage, brain irradiation, or of identified causes of secondary hydrocephalus (subarachnoidal bleeding, meningitis, encephalitis, head trauma).
Key Trial Info
Start Date :
September 1 2005
Trial Type :
INTERVENTIONAL
End Date :
December 1 2007
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT00149721
Start Date
September 1 2005
End Date
December 1 2007
Last Update
March 2 2010
Active Locations (1)
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1
GCRC Johns Hopkins University
Baltimore, Maryland, United States, 21287