Status:
TERMINATED
Effects of Amlodipine in the Management of Chronic Heart Failure
Lead Sponsor:
Rennes University Hospital
Conditions:
Chronic Heart Failure
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
Patients with congestive heart failure are usually treated with a combination of an ACE inhibitor (or an AT1 blocking agent), a diuretic and a beta-blocker. However, some patients remain symptomatic d...
Detailed Description
In patients with congestive heart failure, a treatment with ACE inhibitor combined with digoxin and a diuretic has shown benefits on morbidity and mortality. However, 40% of these patients have persis...
Eligibility Criteria
Inclusion
- Patients over 18 years
- Chronic heart failure with New York Heart Association class III or IV.
- Ischemic or dilated cardiopathy known for at least 3 months
- Systolic arterial pressure \> 110 mmHg under treatment
- Stroke volume between 20 and 40% under treatment
- Informed written consent
Exclusion
- History of allergy to one of the studied pharmaceutical classes
- History of troubles in ventricular rythm (tachycardia, fibrillation) or acute heart failure
- Chronic renal, hepatic or respiratory failure
- Diabetes
- Valvulopathy
- Myocarditis,constrictive pericarditis
- Life prognosis \< 6 months due to a non cardiac pathology
- Absence of woman contraception, pregnancy, breast-feeding
- Treatment with calcium channel blockers or antiarrythmics class IC
- Unstable patient under standardized treatment
- Unable to do a stress test
Key Trial Info
Start Date :
February 10 1999
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
Estimated Enrollment :
7 Patients enrolled
Trial Details
Trial ID
NCT00151619
Start Date
February 10 1999
Last Update
March 26 2019
Active Locations (2)
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1
Service de Réanimation Médicale - Hôpital Raymond Poincaré
Garches, France, 92380
2
Service de Réadaptation Cardio-Vasculaire - Clinique St Yves
Rennes, France, 35044