Status:
TERMINATED
Effect of a Perioperative Oral Nutritional Supplementation on Patients Undergoing Hepatic Surgery for Liver Cancer
Lead Sponsor:
Rennes University Hospital
Collaborating Sponsors:
Ministry of Health, France
Novartis
Conditions:
Liver Cancer
Hepatocellular Carcinoma
Eligibility:
All Genders
18+ years
Phase:
PHASE2
PHASE3
Brief Summary
Cirrhotic patients undergoing hepatic resection have a mortality rate near 10%, and 30 to 70% of them develop severe complications. These failures are mainly due to hepatic insufficiency. Studies have...
Detailed Description
In patients undergoing hepatic resection for liver cancer (with cirrhosis or fibrosis liver), mortality rate can reach 10% and morbidity (ascites, icteria, infections) 70%. These complications are mai...
Eligibility Criteria
Inclusion
- Adult over 18 years
- Hepatectomy of at least 2 segments
- For primary or secondary cancer
- With cirrhosis (Child Pugh \<8) or liver fibrosis (fibrosis score of 3)
- Informed written consent
Exclusion
- Pregnancy
- Recent weight loss of more than 10% of body weight
- Immunological deficiency
- Portal or hepatic arterial thrombosis
- Biliary duct dilation
Key Trial Info
Start Date :
April 1 2003
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2008
Estimated Enrollment :
35 Patients enrolled
Trial Details
Trial ID
NCT00151671
Start Date
April 1 2003
End Date
September 1 2008
Last Update
February 27 2012
Active Locations (1)
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1
Service de Réanimation Chirurgicale - Hôpital Pontchaillou
Rennes, France, 35033