Status:
WITHDRAWN
Effect of Losartan on Retinal Endothelial Function in Patients With Essential Hypertension
Lead Sponsor:
University of Erlangen-Nürnberg Medical School
Collaborating Sponsors:
Merck Sharp & Dohme LLC
Conditions:
Hypertension
Eligibility:
All Genders
18-65 years
Phase:
PHASE2
PHASE3
Brief Summary
Essential hypertension is commonly associated with impaired endothelial function. The retinal vasculature is morphologically and functionally related to the cerebral vessels because of the common orig...
Eligibility Criteria
Inclusion
- Male and female patients aged 18-65 years with essential hypertension
Exclusion
- Secondary forms of hypertension
- Advanced damage of vital organs (grade III and IV retinopathy)
- History of serious hypersensitivity reaction to AT1-receptor blockers
- Actual or anamnestic alcohol- or drug abuse.
- Smokers or ex-smokers \< 1 year.
- Patients with Diabetes mellitus (oral medication or insulin).
- Patients with arterial fibrillation or AV-Block (II° or more).
- Patients with anamnestic myocardial infarction.
- Patients with instable angina pectoris including EcG-aberrations or cardiac insufficiency NYHA III or IV.
- History of malignancy (unless a documented disease-free period exceeding 10 years is present) with teh exception of basal cell carcinoma of the skin
- History of allograft transplantation
- Therapy with not approved concomitant medication, or participation in a clinical study within 4 weeks preceding treatment start.
- Disease which interfere with the pharmacodynamics and pharmacokinetics of the study drug.
- Liver-or kidney disease with SGOT, GPT, g-GT, AP, bilirubin and creatinin or above 200% of standard.
- Patients, who are not sufficiently compliant, or patients, who are not capable or willing to appear for controlling vistas.
- Presumed risk of transmission of HIV or hepatitis via blood from the participant
Key Trial Info
Start Date :
September 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2006
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT00152633
Start Date
September 1 2005
End Date
January 1 2006
Last Update
July 6 2012
Active Locations (1)
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1
CRC, Med. Klinik 4, University of Erlangen-Nürnberg
Erlangen, Germany, 91054