Status:
UNKNOWN
Platelets Induced Vasodilation, in Vitro and in Vivo Study
Lead Sponsor:
University Hospital, Angers
Conditions:
Peripheral Arterial Disease
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
The aim of the study is to show the implication of platelets in vasodilation using in vivo and in vitro analysis and to compare the effects of placebo, aspirin and Clopidogrel in this interaction plat...
Eligibility Criteria
Inclusion
- Inclusion criteria healthy subjects
- Man or Woman 18 years
- Agreement signed
- French health insurance
- Able to understand the study
- Biological haemostatic test normal
- Vascular Doppler of lower limbs normal
- Pressure index \> 1 in both lower limbs
- Inclusion criteria healthy subjects
- Man or Woman 18 years
- Agreement signed
- French health insurance
- Able to understand the study
- Biological haemostatic test normal
- Lower limbs arteriopathy (clinical, pressure index, Doppler)
Exclusion
- Unable to sign agreement
- Subjects protected by low
- Participation to other study
- Changes of treatment within the 15 days before inclusion
- Chronic treatment with Clopidogrel or drugs against inflammation
- Severe respiratory, cardiac, kidney, hepatic insufficiency
- Haemostatic troubles
- Diabetic neuropathy
- Neurologic desease (Parkinson…..)
- Hypertension
- Symptomatic stomach ulcer
- Anaemia Hb\<11g/l
- Pregnant women or breast feeding
Key Trial Info
Start Date :
March 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
January 1 2008
Estimated Enrollment :
36 Patients enrolled
Trial Details
Trial ID
NCT00152646
Start Date
March 1 2005
End Date
January 1 2008
Last Update
February 4 2010
Active Locations (1)
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1
Exploration Fonctionnelles Vasculaires
Angers, Maine et Loire, France, 49933