Status:
COMPLETED
Surgery Versus no Surgery for OA of the Knee
Lead Sponsor:
Fowler Kennedy Sport Medicine Clinic
Collaborating Sponsors:
Canadian Institutes of Health Research (CIHR)
Conditions:
Osteoarthritis
Eligibility:
All Genders
18+ years
Phase:
PHASE3
Brief Summary
The purpose of this trial is to evaluate the effectiveness of arthroscopy (lavage and debridement) in conjunction with the best available non-surgical treatment versus the best available non-surgical ...
Detailed Description
Osteoarthritis is estimated to affect half of the adult population, and by the age of 75 years, it is anticipated that 85 of 100 elderly patients will have some form of this disease. Osteoarthritis (O...
Eligibility Criteria
Inclusion
- Idiopathic or secondary osteoarthritis of the knee as diagnosed by Altman et al 2 classification tree -83 percent sensitivity, 93percent specificity
- Grades 2 to 4 severity of OA by radiographic evaluation- modified Kellgren and Lawrence grading system
- Age greater than 18.
Exclusion
- Inflammatory or post-infection arthritis of the knee
- Previous arthroscopy for treatment of knee OA
- Isolated medial compartment OA Grade 3-4 with greater than 5 degrees mechanical varus -ideal candidate for high tibial osteotomy
- Isolated lateral compartment OA Grade III-IV with greater than 5 degrees mechanical valgus -ideal candidate for high tibial osteotomy or distal femoral osteotomy
- Grade 4 OA in at least 2 compartments and over 60 years of age -ideal candidate for total knee arthroplasty
- Cortico-steroid injection within the last three months.
- Major neurological deficit
- Major medical illness -life expectancy less than 2 years or with unacceptably high operative risk.
- Pregnant
- Unable to speak or read English
- Psychiatric illness that limits informed consent
- Unwilling to be followed for 2 years
Key Trial Info
Start Date :
January 1 1999
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2007
Estimated Enrollment :
186 Patients enrolled
Trial Details
Trial ID
NCT00158431
Start Date
January 1 1999
End Date
August 1 2007
Last Update
November 30 2015
Active Locations (1)
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1
Fowler Kennedy Sport Medicine Clinic
London, Ontario, Canada, N6A 3K7