Status:
TERMINATED
Liver Transplantation in Patients With Hepatitis C Virus (HCV) and Human Immunodeficiency Virus (HIV) Coinfection
Lead Sponsor:
French National Agency for Research on AIDS and Viral Hepatitis
Conditions:
HIV Infections
Hepatitis C
Eligibility:
All Genders
18-69 years
Phase:
PHASE2
Brief Summary
To show the feasibility of liver transplantation in HCV-HIV coinfected patients. To study the two-year survival after transplantation, the interaction between HCV and HIV after transplantation, the in...
Detailed Description
Until recently, HIV infection was considered as a contraindication for liver transplantation. A dramatic improvement in survival of HIV patients have been observed since the advent of new antiviral tr...
Eligibility Criteria
Inclusion
- Coinfection HIV-HVC
- Indication of liver transplantation for severe hepatopathy with life threatening:repetitive ascitis or infection of ascitis or icterus or decreased of prothrombin index under 50 percent or digestive haemorrhage by portal hypertension uncontrolled
Exclusion
- Toxicomania
- Alcohol consumer (over 30g per day)
- AgHBs positive
- hepatocarcinoma over 5 cm or 3 nodules
- CD4 below 200/mm3
- Viral load below 400 cp
- HIV stade C
Key Trial Info
Start Date :
June 1 2002
Trial Type :
INTERVENTIONAL
End Date :
Estimated Enrollment :
15 Patients enrolled
Trial Details
Trial ID
NCT00158535
Start Date
June 1 2002
Last Update
September 12 2005
Active Locations (1)
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1
Centre hepato biliaire hopital paul Brousse
Villejuif, France, 94804 cedex