Status:
COMPLETED
The Effect of Antecedent Hypoglycaemia on β2-adrenergic Sensitivity
Lead Sponsor:
Radboud University Medical Center
Conditions:
Diabetes
Hypoglycemia Unawareness
Eligibility:
All Genders
18-40 years
Phase:
NA
Brief Summary
Hypoglycaemia unawareness is a common complication in patients with type 1 diabetes and with insulin-treated type 2 diabetes of long duration. The loss of autonomic symptoms to hypoglycemia does not s...
Eligibility Criteria
Inclusion
- Informed consent
- Homozygous for Arginine at codon 16 or homozygous Gly at codon 16
- No regular usage of medication other than oral contraceptives
Exclusion
- History of cerebrovascular, cardiovascular, or peripheral vascular disease
- Smoking
- Alcohol usage of more than 10 units per week
- Inability to abstain from xanthine-derivatives (coffee, tea, cola, chocolate, cacao) or alcohol for 2 days
- BMI above 30 kg/m2
- Participation to any other trial in the preceding 3 months
- Ongoing disease of any kind
- Pregnancy
Key Trial Info
Start Date :
April 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 1 2009
Estimated Enrollment :
16 Patients enrolled
Trial Details
Trial ID
NCT00160056
Start Date
April 1 2005
End Date
April 1 2009
Last Update
May 12 2015
Active Locations (1)
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1
Radboud University Nijmegen Medical Centre
Nijmegen, Gelderland, Netherlands, 6500HB