Status:
UNKNOWN
Effects of Potassium Salts on Blood Pressure and Target Organ Damage
Lead Sponsor:
St George's, University of London
Conditions:
Hypertension
Eligibility:
All Genders
18-75 years
Phase:
PHASE3
Brief Summary
The purpose of this study is to determine the effect of potassium chloride and potassium bicarbonate on blood pressure and also to determine whether increasing potassium intake has beneficial effects ...
Detailed Description
Randomised trials have shown that increasing potassium intake lowers blood pressure. However, most previous trials used potassium chloride. Whereas, potassium in fruits and vegetables is not a chlorid...
Eligibility Criteria
Inclusion
- Patients with untreated essential hypertension (sitting systolic blood pressure between 140 and 170 mmHg and/or sitting diastolic blood pressure between 90 and 105 mmHg);
- Age 18 - 75 years.
Exclusion
- Individuals younger than 18 or older than 75 years;
- Individuals with impaired renal function with plasma creatinine greater than 120 umol/L for non-blacks or 150 umol/L for blacks;
- Individuals with chronic diarrhea, or history of peptic ulcer;
- Individuals with baseline plasma potassium values greater than 5.0 mmol/L;
- Individuals with severe hypertension i.e. blood pressure \> 170/105 mmHg;
- Individuals with diabetes mellitus;
- Individuals with any secondary cause of hypertension;
- Individuals with malignancy or liver disease;
- Individuals with ischaemic heart disease or heart failure;
- Females who are pregnant or breast feeding or on the oral contraceptive pill.
Key Trial Info
Start Date :
January 1 2005
Trial Type :
INTERVENTIONAL
End Date :
March 1 2008
Estimated Enrollment :
45 Patients enrolled
Trial Details
Trial ID
NCT00160368
Start Date
January 1 2005
End Date
March 1 2008
Last Update
April 25 2007
Active Locations (1)
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1
St. George's University of London,
London, United Kingdom, SW17 0RE