Status:
COMPLETED
Functional Brain Activation Patterns in Schizophrenia, Measured Before and After Treatment
Lead Sponsor:
UMC Utrecht
Conditions:
Schizophrenia
Schizophreniform Disorders
Eligibility:
All Genders
16-50 years
Brief Summary
In this study we, the investigators at UMC Utrecht, intend to investigate changes in brain activation patterns using functional magnetic resonance imaging (MRI), in patients suffering from schizophren...
Detailed Description
Schizophrenia is a heterogeneous disorder with a wide range of symptoms and signs including hallucinations, delusions, disorganisation, negative symptoms and cognitive deficits. Investigation of the n...
Eligibility Criteria
Inclusion
- Inclusion Criteria (patients):
- Diagnoses of schizophrenia, schizophreniform disorder, schizoaffective disorder or psychotic disorder NOS, confirmed on the basis of Comprehensive Assessment of Symptoms and History (CASH) or a Structured Clinical Interview for DSM-IV Disorders (SCID) interview
- Ages between 16 and 50 years
- CGI of at least 4
- Patients are neuroleptic-naive or medication-free for at least 2 weeks
- Inclusion Criteria (healthy controls):
- No psychiatric disorders (according to Diagnostic and Statistical Manual of Mental Disorders, 4th Edition \[DSM-IV\], Axis I)
- No psychiatric disorders in first degree relatives.
- Ages: between 18 and 50 years old
- Exclusion Criteria (patients and healthy controls):
- Ferrous objects in or around the body
- Neurological or medical illness, including closed head injury.
- Mental retardation.
- Diagnosis of substance dependence within the previous 3 months.
- Pregnancy
- Treatment with antidepressants or mood stabilizers within 3 weeks of inclusion.
Exclusion
Key Trial Info
Start Date :
December 1 2001
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
September 1 2008
Estimated Enrollment :
78 Patients enrolled
Trial Details
Trial ID
NCT00161057
Start Date
December 1 2001
End Date
September 1 2008
Last Update
April 23 2009
Active Locations (1)
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1
Dept. of Psychiatry, UMC Utrecht
Utrecht, Utrecht, Netherlands, 3584 CX