Status:
UNKNOWN
On-Demand Use of Pantoprazole: Determinants for Chronic Use of Acid Suppressive Medication
Lead Sponsor:
UMC Utrecht
Collaborating Sponsors:
Takeda
Conditions:
Chronic Use of Acid Suppressive Medication
GORD
Eligibility:
All Genders
18-75 years
Phase:
PHASE3
Brief Summary
The purpose of this study is to investigate several aspects of chronic use of acid suppressing medication: dependence on maintenance therapy, the possibilities for on-demand use, and predictors (patie...
Detailed Description
2-5% of the general population is chronic user of acid suppressing medication (proton pump inhibitors, H2 receptor antagonists), mostly because of gastro-oesophageal reflux disease (GORD). Prescriptio...
Eligibility Criteria
Inclusion
- male and female (non-pregnant, non-lactating)out-patients between 18-75
- chronic users of acid suppressive therapy for at least 180 days over the last year
Exclusion
- stage 3, 4 oesophagitis, Barrett's oesophagus, acute peptic ulcer
- gastric hypersecretory condition, predominantly IBS symptoms, previous gastric/oesophageal surgery, pyloric stenosis
- severe, unstable comorbidities
- alarm symptoms
- malignancies in the past 5 years
- use of NSAID, systemic glucocorticoids, Cox-2 inhibitors, acetylsalicylic acid more than 150 mg daily, drugs with pH-dependent absorption, anticholinergics
Key Trial Info
Start Date :
March 1 2004
Trial Type :
INTERVENTIONAL
End Date :
September 1 2005
Estimated Enrollment :
276 Patients enrolled
Trial Details
Trial ID
NCT00161096
Start Date
March 1 2004
End Date
September 1 2005
Last Update
February 2 2006
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