Status:
UNKNOWN
Probiotics in Patients With Primary Sclerosing Cholangitis
Lead Sponsor:
UMC Utrecht
Conditions:
Primary Sclerosing Cholangitis
Eligibility:
All Genders
18+ years
Phase:
PHASE3
Brief Summary
PSC is a progressive liver disease without effective medical treatment. There is often co-existent ulcerative colitis. Probiotics (bacterial food supplements) have been shown to benefit patients with ...
Detailed Description
I. INTRODUCTION Primary sclerosing cholangitis (PSC) is a progressive cholestatic liver disease characterized by multifocal strictures of intrahepatic and extrahepatic bile ducts, which frequently lea...
Eligibility Criteria
Inclusion
- Diagnosis of PSC based on characteristic findings on cholangiography, or based on the triad: typical histological findings in a liver biopsy, elevated serum alkaline phosphatase and presence of inflammatory bowel disease
- Presence of inflammatory bowel disease
- elevated serum alkaline phosphatase
- age ≥ 18 years
- informed consent
Exclusion
- Pregnancy
- use of probiotics within one month before the study
- use of antibiotics within one month before the study
- a history of bacterial cholangitis
Key Trial Info
Start Date :
January 1 2005
Trial Type :
INTERVENTIONAL
End Date :
May 1 2006
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT00161148
Start Date
January 1 2005
End Date
May 1 2006
Last Update
January 9 2007
Active Locations (1)
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1
UMC Utrecht
Utrecht, Utrecht, Netherlands, 3508 GA