Status:
COMPLETED
Vancomycin Concentration in Cerebrospinal Fluid During Pneumococcal Meningitis
Lead Sponsor:
Assistance Publique - Hôpitaux de Paris
Conditions:
Pneumococcal Meningitis
Eligibility:
All Genders
18+ years
Brief Summary
Adding vancomycin to the antibiotic regimen is recommended for the treatment of pneumococcal meningitis in adults. Use of dexamethasone as adjunct therapy has proved to reduce mortality and neurologic...
Detailed Description
Because of a considerable increase in streptococcus pneumoniae meningitis with penicillin nonsusceptible strains, it is now largely recommended to add vancomycin to the third-generation cephalosporin ...
Eligibility Criteria
Inclusion
- Adults (\> 18 yr) with suspicion of pneumococcal meningitis requiring intensive care unit
Exclusion
- Allergy to one of the antibiotics used in the study
Key Trial Info
Start Date :
December 1 2002
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
November 1 2005
Estimated Enrollment :
14 Patients enrolled
Trial Details
Trial ID
NCT00162578
Start Date
December 1 2002
End Date
November 1 2005
Last Update
July 23 2007
Active Locations (3)
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1
Service de Réanimation Médicale, CHU Louis Mourier
Colombes, France, 92700
2
Service de Réanimation Médicale, CHU Bichat
Paris, France, 75018
3
Service de Réanimation Médicale, CHI Poissy-St-Germain
Poissy, France, 78300