Status:
COMPLETED
Escitalopram as a Treatment for Pain in Polyneuropathy
Lead Sponsor:
Odense University Hospital
Collaborating Sponsors:
Aarhus University Hospital
H. Lundbeck A/S
Conditions:
Pain
Polyneuropathies
Eligibility:
All Genders
20-80 years
Phase:
PHASE4
Brief Summary
Many people with polyneuropathy suffer from pain which is difficult to treat. Escitalopram is a relatively new drug used in the treatment of depression. Escitalopram's action mechanism on the brain su...
Detailed Description
Tricyclic antidepressants appear to be the most efficacious treatment of painful polyneuropathy. However, these drugs are contraindicated in some patients and a substantial number of patients decline ...
Eligibility Criteria
Inclusion
- median total pain score at baseline week \>=4 on a 10 point numerical rating scale
- characteristic symptoms of polyneuropathy within at least 6 months
- diagnosis confirmed by physical examination, neurophysiologic exam. and/or quantitative sensory testing
- pain at least 4 of 7 days
- fertile women are using anticonceptive
Exclusion
- other cause to pain than polyneuropathy
- former allergic reactions on escitalopram
- known adverse events on escitalopram
- pregnancy or nursing
- critical disease (terminal cancer, cardial incompensation or critical renal or lung disease)
- treatment with monoamine oxidase inhibitors between the trial or 2 weeks before or after treatment with other antidepressants, antiepileptic agents or opioids
Key Trial Info
Start Date :
December 1 2004
Trial Type :
INTERVENTIONAL
End Date :
April 1 2007
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT00162968
Start Date
December 1 2004
End Date
April 1 2007
Last Update
April 24 2007
Active Locations (2)
Enter a location and click search to find clinical trials sorted by distance.
1
Danish Pain Research Center, Aarhus University Hospital, Noerrebrogade 44
Aarhus, Denmark, 8000
2
Dept. of Neurology, Odense University Hospital, Sdr. Boulevard 29
Odense, Denmark, 5000