The Early Nasojejunal Tube to Meet Energy Requirements in Intensive Care (ENTERIC) Study

Status:

UNKNOWN

The Early Nasojejunal Tube to Meet Energy Requirements in Intensive Care (ENTERIC) Study

Lead Sponsor:

Bayside Health

Conditions:

Critical Illness

Malabsorption Syndromes

Eligibility:

All Genders

18+ years

Phase:

Brief Summary

This is a multi-centre randomised controlled trial comparing early jejunal feeding (using a frictional nasojejunal \[NJ\] tube) and standard feeding in critical illness.

Eligibility Criteria

Inclusion

ICU patients are eligible for enrolment if they meet all of the following:
Age \> 18 years old
In ICU for \< 48 hours prior to enrolment
Receiving invasive mechanical ventilation (through an endotracheal tube or tracheostomy, but NOT a facemask) with an anticipated need for \> 48 hours of mechanical ventilation
Receiving a continuous infusion of any one of:
morphine \> 2 mg/hour,
fentanyl \> 20 mcg/hour, or
pethidine \> 20 mg/hour
Either a single GRV \> 150 mls (whilst receiving EN via a NG tube) or nasogastric drainage \> 500 mls over 12 hours (whether receiving EN or not)

Exclusion

Patients will be ineligible for enrolment if they meet any of the following:
Previous or recent surgery which has altered the anatomy of the upper gastrointestinal tract (eg. oesophagectomy, gastrectomy, any gastric anastomosis surgery, gastroplasty, pyloroplasty, pancreaticoduodenectomy \[Whipple's procedure\])
Known gastric malignancy
Known oesophageal varices
Current admission for peptic ulceration
Current mechanical bowel obstruction
Current gastrostomy, jejunostomy, or surgically-placed enteral tube in situ
Contraindication to the use of the nose and mouth for enteral tube insertion (eg. recent facial trauma or surgery)
Receiving nutritional support prior to ICU admission
Severe coagulopathy (defined by platelet count \< 20 and/or international normalized ratio \[INR\] \> 4.0)

Key Trial Info

Start Date :

Trial Type :

INTERVENTIONAL

End Date :

Estimated Enrollment :

180 Patients enrolled

Trial Details

Trial ID

NCT00163813

Last Update

February 26 2007

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