Status:
UNKNOWN
Sympathetic Activity in Individuals With the Metabolic Syndrome: Benefits of Lifestyle Interventions
Lead Sponsor:
Bayside Health
Conditions:
Metabolic Syndrome X
Eligibility:
All Genders
45-65 years
Phase:
NA
Brief Summary
An abdominal distribution of fat is associated with the greatest heart disease risk, because commonly, several risk factors of metabolic origin (high blood pressure, unfavourable cholesterol profile, ...
Detailed Description
Background: Autonomic dysfunction, namely increased sympathetic drive and reduced vagal tone, may participate in the pathogenesis and complications of the MetS. Weight loss and aerobic exercise are f...
Eligibility Criteria
Inclusion
- Sixty six (33 male and 33 postmenopausal female) weight-stable (body mass index 26 to 39 kg/m2), sedentary, non-smoking subjects, aged 45 to 65 years will be recruited on the basis of having \> 3 indices of the MetS as defined by Adult Treatment Panel (ATP) III criteria:
- waist circumference \> 102 cm for men and \> 88 cm for women;
- fasting plasma glucose level \> 6.1 mmol/L, but nondiabetic (\< 7.1 mmol/L);
- fasting plasma triglyceride level \> 1.69 mmol/L;
- plasma high-density lipoprotein (HDL) level \< 1.04 mmol/L (males) and \< 1.29 mmol/L (females);
- supine resting blood pressure \> 130/85 mmHg and \< 165/105 mmHg, at least 4 weeks off blood pressure lowering medications.
Exclusion
- Exclusion criteria will comprise:
- A history of diabetes, secondary hypertension, sleep apnoea, cardiovascular, cerebrovascular, renal, liver, or thyroid disease
- Inability to cease medications which may affect measured parameters
- Inability or contraindication to exercise
Key Trial Info
Start Date :
April 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2007
Estimated Enrollment :
66 Patients enrolled
Trial Details
Trial ID
NCT00163943
Start Date
April 1 2005
End Date
December 1 2007
Last Update
August 1 2007
Active Locations (1)
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1
Baker Heart Research Institute
Melbourne, Victoria, Australia, 8008