Status:
COMPLETED
A Study Comparing High Dose Omeprazole Infusion Against Scheduled Second Endoscopy for Bleeding Peptic Ulcer
Lead Sponsor:
Chinese University of Hong Kong
Conditions:
Peptic Ulcer Hemorrhage
Eligibility:
All Genders
18-90 years
Phase:
PHASE3
Brief Summary
A prospective randomized study to compare the adjunctive use of high dose omeprazole infusion against scheduled second endoscopy in prevention of peptic ulcer rebleeding after therapeutic endoscopy.
Detailed Description
We have previously performed a prospective randomized controlled trial on the effect of scheduled second endoscopy upon peptic ulcer rebleeding. We found that the rate of recurrent bleeding was signif...
Eligibility Criteria
Inclusion
- all consecutive patients admitted for peptic ulcer bleeding (including bleeding anastomotic ulcers) with emergency endoscopy done in 24 hours after admission with Forrest type Ia, Ib, and IIa, IIb
- age 15 - 90 years
- Written consent available
Exclusion
- ulcer bleeding not controlled in first endoscopy
- Bleeding from malignant ulcer or tumor
- Bleeding from Dieulafoy lesion/ angiodysplasia
- Bleeding from injection sclerotherapy ulcer
- Patient with ASA category 5
Key Trial Info
Start Date :
October 1 2003
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
Estimated Enrollment :
240 Patients enrolled
Trial Details
Trial ID
NCT00164931
Start Date
October 1 2003
Last Update
June 10 2011
Active Locations (1)
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1
Department of Surgery, United Christian Hospital
Hong Kong, China