Status:
COMPLETED
Screening for Colorectal Neoplasm in First Degree Relatives of the Affected
Lead Sponsor:
Chinese University of Hong Kong
Conditions:
Colorectal Cancer Screening
Eligibility:
All Genders
40-70 years
Brief Summary
To determine the prevalence of colorectal neoplasms in first degree relatives of those affected with sporadic colorectal cancer using colonoscopy as a screening tool. The prevalence will be compared t...
Detailed Description
Colorectal cancer is a second commonest tumor in Hong Kong and the second commonest cause of cancer related death. About 1 in 23 males will develop colorectal cancer in his life time. The disease tend...
Eligibility Criteria
Inclusion
- First degree relatives (age \>40 and \<70) of individuals affected with sporadic colorectal cancer (those not associated with inflammatory bowel disease, familial adenomatous polyposis or HNPCC syndrome).
Exclusion
- A family history compatible with that of Hereditary Non-polyposis Colon Cancer (HNPCC) based on the Amsterdam criteria \[Table 5\].
- Known Familial Adenomatous Polyposis (FAP) syndrome
- Patients and relatives with known inflammatory bowel disease
- Relatives that have received colonoscopy examinations in the past 5 years \[details of colonoscopic examinations will be sought and information on colonic neoplasms recorded\]. Those who have had barium enema examinations are eligible for trial inclusion as barium examinations often have low sensitivity and specificity for adenomas (around 70% respectively)
- Severe cardio-pulmonary or other medical co-morbidities that preclude safe colonoscopic examination
Key Trial Info
Start Date :
April 1 2004
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
April 6 2017
Estimated Enrollment :
748 Patients enrolled
Trial Details
Trial ID
NCT00164944
Start Date
April 1 2004
End Date
April 6 2017
Last Update
April 21 2017
Active Locations (1)
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1
Endoscopy Center, Prince of Wales Hospital
Hong Kong (sar), China