Status:
COMPLETED
The Role of Methycobalamin in Early Dementia Patients With Vitamin B12 Deficiency and Hyperhomocysteinaemia.
Lead Sponsor:
Eisai Co., Ltd.
Conditions:
Dementia With Vitamin B12 Deficiency
Eligibility:
All Genders
60+ years
Phase:
PHASE4
Brief Summary
Patients who fit the inclusion criteria are admitted into the study. They are given 3 IV injection of MBL in the first week and one tablet three times a day for 16 weeks.
Eligibility Criteria
Inclusion
- Inclusion:
- Patients with Dementia
- Serum B12 \< 200 pmol/l
- Serum Homocysteine level \> 11.0 micro mol/L
- Exclusion:
- Significant communication problems
- deafness, dysarthria, dysphasia etc.
- unstable DM or hypertension
- alcohol abuse
- co-existing diseases which may affect cognition e.g. cognitive cardiac failure, respiratory failure
- folate \< 10 g/dl
- haemoglobin concentration \< 10g/d
- abnormal thyroid function test or VDRL
Exclusion
Key Trial Info
Start Date :
March 1 2003
Trial Type :
INTERVENTIONAL
End Date :
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT00165711
Start Date
March 1 2003
Last Update
February 19 2019
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Chinese University of Hong Kong
Hong Kong, Hong Kong, China