Status:
COMPLETED
Cytokines Polymorphisms and Acetaminophen Toxicity
Lead Sponsor:
Arkansas Children's Hospital Research Institute
Collaborating Sponsors:
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Conditions:
Drug Toxicity
Eligibility:
All Genders
Brief Summary
Genotyping assays for polymorphisms in the interleukin 10(IL10)gene and the inducible nitric oxide synthase (iNOS) gene will be performed. Genotypes will be compared to the severity of toxicity follow...
Detailed Description
It was recently reported that IL-10 is protective in Acetaminophen (APAP) toxicity and it down-regulates iNOS production. In an ongoing Pediatric Pharmacology Research Unit (PPRU) Network study, plasm...
Eligibility Criteria
Inclusion
- Males and females of any age admitted to a participating site for acetaminophen overdose (acute or chronic).
Exclusion
- Patients who are unable to tolerate study procedures.
Key Trial Info
Start Date :
December 1 2002
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
September 1 2007
Estimated Enrollment :
111 Patients enrolled
Trial Details
Trial ID
NCT00166608
Start Date
December 1 2002
End Date
September 1 2007
Last Update
April 12 2012
Active Locations (7)
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1
Arkansas Children's Hospital
Little Rock, Arkansas, United States, 72202
2
Kosair Children's Hospital
Louisville, Kentucky, United States, 40202
3
Children's Hospital of Michigan
Detroit, Michigan, United States, 48201
4
Children's Mercy Hospital
Kansas City, Missouri, United States, 64108