Status:
COMPLETED
Cognitive Enhancement Therapy for Early-Stage Schizophrenia
Lead Sponsor:
Beth Israel Deaconess Medical Center
Collaborating Sponsors:
National Institute of Mental Health (NIMH)
Conditions:
Schizophrenia
Eligibility:
All Genders
16-51 years
Phase:
PHASE3
Brief Summary
This study will determine the effectiveness of cognitive enhancement therapy (CET) in treating cognitive abnormalities in people experiencing the early stages of schizophrenia.
Detailed Description
In this study, we wish to determine the neurobiological predictors and the relative efficacy of Cognitive Enhancement Therapy (CET) in ameliorating specific cognitive abnormalities presumably mediated...
Eligibility Criteria
Inclusion
- DSM-IV diagnosis of schizophrenia, schizoaffective or schizophreniform disorder at the time of initial assessment
- Pre-treatment illness duration an average of 5 years, not to exceed 8 years
- Stable positive symptoms (e.g., if present do not grossly interfere with behavior such as command hallucinations or delusions)
- Currently maintained and compliant with prescribed antipsychotic medication
- Socially and cognitively disabled, e.g., meet criteria on a Cognitive Style Scale (score greater than or equal to 7), and Social Cognition Disability Scale (score greater than or equal to 12).
Exclusion
- Alcohol/drug abuse or dependence that has significantly interfered with adjustment in the past two months (e.g., patients currently undergoing D and A treatment must successfully complete their recovery program prior to referral)
- Organic brain syndrome, including HIV illness (due to its effect on CNS function)
- IQ below 80 or language skills below the sixth grade level
- Medical contraindications that preclude an appropriate antipsychotic medication
- Persistent suicidality
Key Trial Info
Start Date :
August 1 2001
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2016
Estimated Enrollment :
67 Patients enrolled
Trial Details
Trial ID
NCT00167362
Start Date
August 1 2001
End Date
December 1 2016
Last Update
January 10 2017
Active Locations (1)
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1
University of Pittsburgh
Pittsburgh, Pennsylvania, United States, 15213