Status:
COMPLETED
Prazosin Alcohol Dependence IVR Study
Lead Sponsor:
University of Washington
Collaborating Sponsors:
US Department of Veterans Affairs
Conditions:
Alcoholism
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
This double-blind placebo controlled pilot trial will test the hypothesis that prazosin, an alpha-1 adrenergic receptor antagonist, reduced alcohol consumption and alcohol craving in alcohol dependent...
Detailed Description
The objective of the project is to determine whether prazosin, an alpha-1 adrenergic receptor antagonist, decreases alcohol consumption and/or the subjective experience of alcohol craving in individua...
Eligibility Criteria
Inclusion
- age 18 years of age or older
- current DSM-IV diagnosis of alcohol dependence with some use in last 30 days
- capacity to provide informed consent
- no planned absences during six week active treatment period that would prevent weekly check-in wiht the study psychiatrist
- English fluency
Exclusion
- Score 50 or greater on the PTSD Check List which suggests a current diagnosis of PTSD
- Psychiatric disorder requiring any medication other than anti-depressants
- Current diagnosis of opiate dependence or abuse, chronic treatment with any opiate-containing medications during the previous month, or urine positive for opioids
- Significant acute or chronic medical illness, including unstable angina, recent myocardial infarction, history of congestive heart failure, preexisting hypotension (systolic lower than 110) or orthostatic hypotension (systolic drop greater than 20mmHg after two minutes standing or any drop with dizziness), insulin-dependent diabetes mellitus; chronic renal or hepatic failure, pancreatitis, gout, Meniere's disease, benign positional vertigo, narcolepsy
- Concomitant use of trazodone, tadalafil or verdenafil
- History of prazosin-sensitivity
- Women who are pregnant, nursing infant(s), or of childbearing potential and not using a contraceptive method judged by the investigator to be effective
- Signs or symptoms of alcohol withdrawal at the time of randomization
Key Trial Info
Start Date :
September 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2007
Estimated Enrollment :
23 Patients enrolled
Trial Details
Trial ID
NCT00167687
Start Date
September 1 2005
End Date
October 1 2007
Last Update
February 15 2008
Active Locations (1)
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1
VA Puget Sound Health Care System
Seattle, Washington, United States, 98108