Status:
COMPLETED
Treatment of Fever Due to Malaria With Ibuprofen
Lead Sponsor:
Albert Schweitzer Hospital
Conditions:
Fever
Eligibility:
All Genders
2-7 years
Phase:
PHASE4
Brief Summary
Drugs to treat fever are widely used in children with fever. But there is a controversy about the benefit of reducing fever in children with malaria. Ibuprofen is often used to treat malarial fever. T...
Detailed Description
Fever is the most apparent clinical manifestation of Plasmodium falciparum infection during the acute phase. The role of fever in defence against malaria or in other infectious diseases remains unclea...
Eligibility Criteria
Inclusion
- Uncomplicated falciparum malaria
- Asexual parasitaemia between 20,000 and 200,000/µL
- Fever with temperature above 38 °C or history of fever during the preceding 24 hours
- Informed consent
Exclusion
- Effective anti-malarial treatment for the present attack
- Antipyretic use within 6 hours of presentation
- Contraindications to the use of ibuprofen (history of asthma, dyspeptic symptoms, gastro-intestinal bleeding, or allergy to ibuprofen)
- Mixed plasmodial infection
- Haemoglobin \< 7 g/dL
- Packed-cell volume \< 20%
- White cell count \> 16,000/L
- Platelet count \< 40,000/µL
- Schizontaemia \> 50/µL
- Impaired consciousness
- Convulsions or history of convulsions
- Concomitant diseases masking assessment of response
Key Trial Info
Start Date :
April 1 2003
Trial Type :
INTERVENTIONAL
End Date :
January 1 2004
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT00167713
Start Date
April 1 2003
End Date
January 1 2004
Last Update
September 21 2005
Active Locations (1)
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1
Medical research Unit, Lambaréné
Lambaréné, Moyen-Ogooué Province, Gabon, B.P. 118