Status:
COMPLETED
The Use of Platelet Derived Growth Factors in Total Knee Arthroplasty, a Randomized Trial
Lead Sponsor:
Westfries Hospital
Conditions:
Osteoarthritis
Eligibility:
All Genders
18+ years
Phase:
PHASE3
Brief Summary
The objective of this study is to evaluate the effect of autologous platelet concentrate on blood loss (post-operative decrease of haemoglobin concentration), wound healing complications, range of mot...
Detailed Description
The short-term functional recovery after a total knee arthroplasty (TKA) is largely dependent on initial wound healing. Haematoma formation may lead to prolonged wound drainage and tissue necrosis1, w...
Eligibility Criteria
Inclusion
- Patients undergoing primary total knee arthroplasty for primary osteoarthritis
Exclusion
- Coagulation disorder
- Abnormal pre-operative levels of APTT, PT and/or thrombocytes
- Homologous blood transfusion last 4 weeks
- Coagulation disorder
- Use of anticoagulation medication
- Use of any iron supplements or erythropoietin at time of operation or during 1 week prior to operation
- Primary bone tumor or metastatic bone disease
- Unable or unwilling to participate in follow-up
- Unable to give informed consent
- Previous infection in knee
- Use of corticosteroids at time of operation or during 4 weeks prior to operation
- Any neuromuscular disorder
- Active infection or osteomyelitis
Key Trial Info
Start Date :
October 1 2004
Trial Type :
INTERVENTIONAL
End Date :
December 1 2006
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT00167895
Start Date
October 1 2004
End Date
December 1 2006
Last Update
April 25 2007
Active Locations (1)
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1
Westfries Gasthuis
Hoorn, Netherlands, 1620AR