Status:
COMPLETED
Community Based Trial for AMEVIVE®
Lead Sponsor:
Astellas Pharma Inc
Collaborating Sponsors:
Biogen
Conditions:
Moderate to Severe Chronic Plaque Psoriasis
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
To evaluate the safety of treating subjects with up to 12 additional doses of alefacept.
Detailed Description
Male and female subjects at least 18 years of age with moderate to severe plaque psoriasis treated with 12 weeks of alefacept 15 mg IM and who have not achieved the desired response. Dosing Groups: S...
Eligibility Criteria
Inclusion
- Must give written informed consent.
- Must have had moderate, moderately severe or severe chronic plaque psoriasis as determined by the investigator prior to initial treatment (baseline) with AMEVIVE.
- Must be 18 years of age or older.
- Must have completed a standard 12-week course of AMEVIVE and have received at least 10 doses.
- Response to current AMEVIVE therapy must be less than a desired response as determined by the physician, and subject and some residual psoriasis must be present.
Exclusion
- Female subjects who are not postmenopausal for at least 1 year, surgically sterile, or not willing to practice effective contraception during the study.
- Nursing mothers, pregnant women, and women planning to become pregnant
- Current enrollment in any investigational study in which the subject is receiving any type of drug, biologic, or non-drug therapy.
- Treatment with another investigational drug, or approved therapy for investigational use, within 3 months of investigational drug administration.
- Treatment with systemic retinoids, systemic steroids, methotrexate, cyclosporine, azathioprine, thioguanine, etanercept, efalizumab, infliximab, adalimumab or mycophenolate mofetil or other systemic immunosuppressant agents within 4 weeks of investigational drug administration.
- Treatment with Ultraviolet B (UVB) phototherapy or Psoralen + Ultraviolet A (PUVA), within 4 weeks of investigational drug administration.
- Serious local infection (e.g., cellulitis, abscess) or systemic infection (e.g., pneumonia, septicemia) within the 3 months prior to the first dose of investigational drug.
- History of \>3 cutaneous squamous cell carcinomas or any systemic malignancy.
- Skin lesions suspicious for malignancy.
- Known HIV, viral hepatitis, or tuberculosis infection.
- History of severe allergic or anaphylactic reactions.
- ALT or AST greater than three times the upper limit of normal.
- Significantly abnormal hematology (hemoglobin, hematocrit, platelets, white blood cells), as determined by the investigator.
- CD4+ T lymphocyte count at screening visit less than 250 cells/mm3.
- Known hypersensitivity to AMEVIVE or any of its components.
- Subject's inability to comply with study requirements.
Key Trial Info
Start Date :
July 1 2004
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2005
Estimated Enrollment :
114 Patients enrolled
Trial Details
Trial ID
NCT00168753
Start Date
July 1 2004
End Date
March 1 2005
Last Update
September 8 2014
Active Locations (36)
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1
Monheit Dermatology Associates
Birmingham, Alabama, United States, 35203
2
Bayshore Dermatology
Fairhope, Alabama, United States, 36532
3
Jayne Fortson
Anchorage, Alaska, United States, 99501
4
Bakersfield Dermatology & Skin Cancer Medical Group
Bakersfield, California, United States, 93301