Status:
COMPLETED
Beta-carotene and Alpha-tocopherol Chemoprevention of Second Primary Malignancies in Head and Neck Cancer Patients
Lead Sponsor:
Laval University
Collaborating Sponsors:
Canadian Cancer Trials Group
National Cancer Institute (NCI)
Conditions:
Neoplasms
Eligibility:
All Genders
18+ years
Phase:
PHASE3
Brief Summary
Epidemiologic studies suggest that low dietary intakes and low plasma concentrations of antioxidant vitamins and minerals are associated with increased risks of cancer, especially for epidermoid tumor...
Eligibility Criteria
Inclusion
- Histologically documented stage I or II head and neck cancer
Exclusion
- Karnofsky performance score of less than 60
- Multiple primary head and neck cancer
- History of cancer
- Severe cardiovascular disease
- Inadequate renal, hepatic or hematologic function
- Anticoagulant therapy
- Pregnancy
- Average daily supplement intake of beta-carotene or vitamin E in the preceding year greater than 6.0 mg and 50 IU, respectively.
Key Trial Info
Start Date :
October 1 1994
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2018
Estimated Enrollment :
540 Patients enrolled
Trial Details
Trial ID
NCT00169845
Start Date
October 1 1994
End Date
March 1 2018
Last Update
March 14 2018
Active Locations (1)
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1
Laval University Cancer Research Center
Québec, Quebec, Canada, G1R 2J6