Status:
UNKNOWN
The Effect of Beta-Blockers and Aspirin on Hemostasis and Endothelial Function After Acute Mental Stress
Lead Sponsor:
Swiss Federal Institute of Technology
Collaborating Sponsors:
Swiss National Science Foundation
Conditions:
Arteriosclerosis
Stress, Psychological
Eligibility:
All Genders
40-55 years
Phase:
PHASE1
PHASE2
Brief Summary
This randomized double-blinded controlled trial uses a factorial design to investigate whether application of beta-blockers (inderal 80 mg) or aspirin (100 mg) or a combination thereof has an effect o...
Detailed Description
Background: Population based studies have established hemostatic abnormalities as independent risk factors for atherosclerosis and related adverse outcomes. These abnormalities are characterized as pr...
Eligibility Criteria
Inclusion
- Life-time non-smoker or non-smoker for more than a year,
- native language Swiss-German,
- systolic blood pressure \<160 mm Hg, diastolic blood pressure \<100 mm Hg.
- Subjects must have a body mass index that is not considered to be a cardiovascular risk factor, i.e. ≤ 26.5 kg/m2.
Exclusion
- Individuals reporting cardiovascular disease, renal disorders, endocrine disorders, hepatopathy, psychiatric disorders or who take regular medication for any of these conditions.
- Persons are excluded, who report to drink \>5 cups (0.15 l each) of brewed coffee (\> 500 mg caffeine) a day, or who report drink more than 1.0 l beer and 0.45 l wine per day, respectively.
- All subjects on regular beta-blocking or aspirin medication are excluded from the study.
- Participants will be required not to take aspirin or any other non-steroidal anti-inflammatory drug during the study period, beginning 10 days prior to the first study medication.
Key Trial Info
Start Date :
October 1 2003
Trial Type :
INTERVENTIONAL
End Date :
August 1 2004
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT00174902
Start Date
October 1 2003
End Date
August 1 2004
Last Update
October 25 2006
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Institute of Behavioral Sciences, Swiss Federal Institute of Technology
Zurich, Switzerland, CH-8092