Status:
COMPLETED
Effect of Dietary Amino Acid Profile on Lipoprotein Metabolism, Vascular Reactivity and Inflammatory Markers
Lead Sponsor:
Tufts University
Conditions:
Hyperlipidemias
Metabolic Syndrome X
Eligibility:
All Genders
50-85 years
Phase:
NA
Brief Summary
The aim of this study is to explore the significance of the Lys:Arg ratio on responses of lipids and lipoprotein concentrations to dietary proteins and to evaluate the effects of dietary Lys:Arg on ca...
Detailed Description
Findings from early studies in a variety of experimental models of atherosclerosis on the effect of dietary protein suggested that proteins from vegetable sources are less cholesterolemic and atheroge...
Eligibility Criteria
Inclusion
- Age: 50-85 years
- LDL-C concentrations \>120 mg/dL
Exclusion
- Use of medications known to affect lipid metabolism
- Established cardiovascular disease
- Renal disease
- Liver disease
- Thyroid disease unless controlled with medication for at least 6 months
- Type I and II diabetes
- Irritable bowel syndrome
- Chronic use of prescription anti-inflammatory medications
- Smoking
- Alcohol intake \>7 alcoholic drinks per week
- Unwillingness to maintain body weight during participation in the study
- triglyceride (TG) \> 400 mg/dL
- Unwillingness to adhere to diet and study protocol
- Weight gain or loss of more than 15 lb within 6 months prior to enrollment
Key Trial Info
Start Date :
October 1 2004
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2012
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT00175084
Start Date
October 1 2004
End Date
December 1 2012
Last Update
May 23 2014
Active Locations (1)
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1
Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University
Boston, Massachusetts, United States, 02111