Status:
COMPLETED
Vancomycin Study: Treatment of Catheter Related Bloodstream Infection Caused by Coagulase Negative Staphylococcus
Lead Sponsor:
University of British Columbia
Conditions:
Staphylococcal Infections
Eligibility:
All Genders
16+ years
Phase:
NA
Brief Summary
Patients admitted into the Intensive Care Unit (ICU) have an intravenous (IV) catheter (small plastic tube) placed in their vein. Very occasionally (4 times out of 100) the insertion of an intravenous...
Detailed Description
INTRODUCTION: Intravascular device associated bacteremia due to coagulase negative staphylococcus has become the most common nosocomial bacteremia. Despite its prevalence, no prospective study has inv...
Eligibility Criteria
Inclusion
- Patients admitted to the ICU who require treatment for suspected or documented intravascular device associated (IVDA) bacteremia due to coagulase-negative staphylococci (CNS). Suspected IVDA bacteremia due to CNS is defined as finding of gram positive cocci in blood in a patient with either an intravascular device (IVD) in situ or within 24 hours of catheter removal, with clinical signs of sepsis:
- two signs of systemic inflammatory response syndrome (SIRS): heart rate (HR) \> 90, Temp \> 38 or \< 36, white blood cell (WBC) \> 12 or \< 4, respiratory rate (RR) \> 20 or pCO2 \< 32; and
- with no obvious source of bacteremia other than the IVD.
Exclusion
- Underlying valvular heart disease
- Prosthetic valve or graft
- A history of infectious endocarditis
- Bone marrow transplant recipient
- Neutropenia (\< 0.5 X 10\^9/L)
- Solid organ transplant recipient
- Known hypersensitivity to vancomycin
- Calculated creatinine clearance \< 25 ml/min
Key Trial Info
Start Date :
September 1 2000
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2007
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT00175370
Start Date
September 1 2000
End Date
December 1 2007
Last Update
June 20 2008
Active Locations (1)
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1
Vancouver General Hospital Intensive Care Unit
Vancouver, British Columbia, Canada, V5Z 1M9