Status:
COMPLETED
V3: Vancouver-Victoria Valacyclovir Trial for Early Psychosis
Lead Sponsor:
University of British Columbia
Collaborating Sponsors:
Stanley Medical Research Institute
Conditions:
Psychosis
Eligibility:
All Genders
18-65 years
Phase:
PHASE2
Brief Summary
This is an 18 week (2 weeks run-in, 16 weeks double blind) trial, to determine if an antiviral drug, valacyclovir (Valtrex) is helpful in treating the symptoms of psychosis, a form of a mental disorde...
Detailed Description
There is evidence that some of the symptoms of psychosis may be related to past infection with common viruses. Researchers are looking to recruit a total of 100 subjects with evidence in the past, of...
Eligibility Criteria
Inclusion
- Subjects antipsychotic, mood stabilizing and antidepressant drug treatment must have been stable for at least 3 months, and there is no plan to change the drug treatment during the 4-month phase of the study.
- Subjects must be seropositive for HSV-1, HSV-2 and/or CMV.
- Subjects must achieve a level of understanding and expressive capacity sufficient to communicate adequately with the study coordinator and to participate in cognitive testing.
- Subjects must be able to provide written informed consent.
Exclusion
- Females of childbearing age will agree not to become pregnant and will agree to use a medically acceptable method of birth control.
- Inability to participate in cognitive testing due to severe persistent psychosis or other condition.
- Mental handicap.
- Subjects with known hypersensitivity or allergy to valacyclovir or acyclovir.
- Patient taking nontopical antiviral medications with anti-herpes activity on a regular basis
Key Trial Info
Start Date :
September 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 1 2009
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT00175513
Start Date
September 1 2005
End Date
September 1 2009
Last Update
April 14 2011
Active Locations (2)
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1
Eric Martin Pavilion
Victoria, British Columbia, Canada
2
Peace Arch Hospital
White Rock, British Columbia, Canada