Status:
COMPLETED
Influence of Bedrest and Hypocaloric Nutrition on Endothelium-Dependent Vasoreactivity
Lead Sponsor:
Heidelberg University
Conditions:
Healthy
Eligibility:
MALE
18-40 years
Phase:
PHASE1
Brief Summary
Aim of the study is to assess the impact of the factors ´bed rest´ and ´hypocaloric nutrition´ on endothelium-dependent vasoreactivity in healthy volunteers.
Detailed Description
In a randomized, four-phase cross-over study the effect of simulated microgravity (13 days of bed rest), energetic restriction (-25%, fat reduced), and their combination on endothelium-dependent and -...
Eligibility Criteria
Inclusion
- ´
- Healthy, male volunteers, age: 18-40
- Able and willing to give written informed consent
Exclusion
- Known condition causing endothelial dysfunction (e.g. diabetes, hyperlipidaemia, arterial hypertension, smoking, hyperhomocysteinaemia)
- Regular medication and/or treatment with drugs within the last 4-6 weeks (exclusion has to be decided in each case)
- Acute or chronic illness
- Participation in clinical trial/blood donation within 2 month before the study
- Nicotine during 1 year before the study; drug and/or alcohol abuse.
Key Trial Info
Start Date :
March 1 2001
Trial Type :
INTERVENTIONAL
End Date :
April 1 2003
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT00175968
Start Date
March 1 2001
End Date
April 1 2003
Last Update
September 15 2005
Active Locations (1)
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1
DLR Institute of Aerospace Medicine
Cologne, North Rhine-Westphalia, Germany, D-51170