Status:

COMPLETED

Leipzig Exercise Intervention in Chronic Heart Failure and Aging

Lead Sponsor:

University of Leipzig

Collaborating Sponsors:

German Research Foundation

Conditions:

Heart Failure

Ageing

Eligibility:

All Genders

18-85 years

Phase:

PHASE2

Brief Summary

In both ageing and heart failure progressive exercise intolerance is observed. The Leipzig Exercise Intervention in Chronic heart failure and Aging (LEICA) study aims to investigate how aerobic short-...

Detailed Description

A total of 60 healthy subjects and 60 heart failure patients (in each group 30 \<55 years, 30 \>65 years) are prospectively randomized to either 4 weeks of aerobic ergometer training or control group....

Eligibility Criteria

Inclusion

  • Group 1: Healthy subjects
  • normal left ventricular ejection fraction (EF) \>55%
  • normal coronary artery disease (cardiac catheterization)
  • Group 2: CHF patients
  • reduced left ventricular ejection fraction (EF) \<40%
  • stable clinical condition (NYHA II-III)

Exclusion

  • COLD
  • cardiac decompensation \<3 months
  • ventricular arrhythmias \>Lown IVb
  • myocardial infarction \< 4 weeks
  • valvular heart disease \>II°
  • insulin-dependent diabetes mellitus
  • arterial hypertension
  • orthopedic conditions prohibiting training participation

Key Trial Info

Start Date :

May 1 2005

Trial Type :

INTERVENTIONAL

Allocation :

ACTUAL

End Date :

Estimated Enrollment :

120 Patients enrolled

Trial Details

Trial ID

NCT00176319

Start Date

May 1 2005

Last Update

July 15 2009

Active Locations (1)

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Universität Leipzig, Herzzentrum, Klinik für Innere Medizin/Kardiologie

Leipzig, Saxony, Germany, 04289