Status:
COMPLETED
Plaquenil for Alopecia Areata, Alopecia Totalis
Lead Sponsor:
Hordinsky, Maria K., MD
Conditions:
Alopecia Areata
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
Alopecia areata is an autoimmune condition resulting in hair loss and complete baldness (alopecia totalis). Published evidence says that it is mediated by T-lymphocytes. Plaquenil is an anti-inflammat...
Detailed Description
Alopecia areata is a high prevalence autoimmune disease with significant consequences. Alopecia areata is a tissue restricted autoimmune disease directed at the hair follicle, resulting in hair loss. ...
Eligibility Criteria
Inclusion
- 1\. Severe alopecia areata: \>75% loss of scalp hair or alopecia areata totalis: 100% loss of scalp hair above with or without loss of body hair (alopecia universalis) 2. Group I (8 subjects): Duration of disease less than 1 year 3. Group II (8 subjects): Duration of disease greater than 1 year 4. At least 18 years old 5. Able to give consent.
Exclusion
- 1\. Coexisting significant systemic disease that would increase risk of hydroxychloroquine (e.g. renal disease, liver disease, alcoholism, anemia, blood dyscrasia, psoriasis, porphyria) 2. Systemic immunosuppressive therapy within 3 weeks (e.g. prednisone, cyclosporin, azathioprine) 3. Immunosuppressive conditions (e.g. HIV infection, cancer immunotherapy genetic immunodeficiency 4. Medications with potential interaction to hydroxychloroquine (e.g. liver toxins, bone marrow toxins) 5. Pregnancy, or breast feeding 6. Women of child bearing potential not able or willing to use two methods of contraception at least one of which is not a hypersensitivity to 4-aminoquinolone compounds (chloroquine and hydroxychloroquine) 9. Glucose-6-phosphate deficiency.
Key Trial Info
Start Date :
April 1 2002
Trial Type :
INTERVENTIONAL
End Date :
January 1 2008
Estimated Enrollment :
16 Patients enrolled
Trial Details
Trial ID
NCT00176982
Start Date
April 1 2002
End Date
January 1 2008
Last Update
August 13 2009
Active Locations (2)
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1
University of Minnesota
Minneapolis, Minnesota, United States, 55455
2
State University of New York at Stony Brook
Stony Brook, New York, United States, 11790