Status:
COMPLETED
L-carnosine for Schizophrenia
Lead Sponsor:
University of Pittsburgh
Collaborating Sponsors:
Stanley Medical Research Institute
Conditions:
Schizophrenia
Schizoaffective Disorder
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
The investigators' hypothesis is that oral L-carnosine treatment (as compared with placebo) will enhance cognitive abilities (specifically: measures of attention, executive function, working memory, v...
Detailed Description
OBJECTIVE: Based on the available neuroscience and human data, we hypothesize that supplemental L-carnosine treatment (a potent naturally occuring antioxidant and anti-glycation agent) will be a usef...
Eligibility Criteria
Inclusion
- DSM-IV-TR diagnosis of schizophrenia (any subtype, except currently catatonic) or schizoaffective disorder
- Ages 18 to 65 years
- Men or women
- Ability to read and communicate in English
- 8th grade education or greater
- Ability to provide informed, competent and written consent
- Current antipsychotic medication is stable for greater than or equal to 4 weeks.
Exclusion
- Medically unstable conditions
- Known allergy to L-carnosine
- Current cognitive decline is attributable to a diagnosis of dementia or other neurological disorder
- Pregnant or lactating women
- Mini-mental state examination score (MMSE) less than or equal to 23
- HIV positive status resulting in AIDS-related dementia.
Key Trial Info
Start Date :
March 1 2004
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2007
Estimated Enrollment :
84 Patients enrolled
Trial Details
Trial ID
NCT00177177
Start Date
March 1 2004
End Date
December 1 2007
Last Update
January 16 2013
Active Locations (4)
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1
Mayview State Hospital
Bridgeville, Pennsylvania, United States, 15107-1599
2
Dubois Regional Medical Center
DuBois, Pennsylvania, United States, 15801
3
Mon-Yough Community Services, Inc.
McKeesport, Pennsylvania, United States, 15132
4
Western Psychiatric Institute and Clinic
Pittsburgh, Pennsylvania, United States, 15213