Status:
COMPLETED
Safety Study of S-CKD602 in Patients With Advanced Malignancies
Lead Sponsor:
University of Pittsburgh
Collaborating Sponsors:
ALZA
Conditions:
Cancer
Eligibility:
All Genders
18+ years
Phase:
PHASE1
Brief Summary
The purpose of this research study is to evaluate a new anti-cancer drug called S CKD602, developed by ALZA Corporation. The drug is investigational and not approved by the Food and Drug administratio...
Detailed Description
The main purposes of this study are: To determine the maximum tolerated dose (highest dose that can safely be given to subjects) of S CKD602 when given every three weeks. To determine the incidence ...
Eligibility Criteria
Inclusion
- Male or female subjects with an age \> 18 years Histologically or cytologically proven malignancy, unresponsive to curative surgery, radiotherapy, conventional chemotherapy or for which no conventional therapy exists. (Measurable or evaluable disease is desirable, but not required) Note: This study is restricted to patients with advanced solid tumors, subjects with hematological malignancies are excluded (including lymphoma and leukemia) ECOG Performance Status 0- 2 Adequate bone marrow function, without the support of cytokines and/or Epoetin Alpha within 5 days prior to dosing: Absolute neutrophil count (ANC) \>1,500/mm3, platelet count \> 100,000/mm3, Hgb \> 9.0 g/dL. Adequate liver function: total bilirubin level \< 2.0 mg/dL, ALT and AST \< 2.0 x institutional upper limit of normal in the absence of liver metastasis, or \< 4.0 x institutional upper limit of normal in the presence of liver metastasis.
- Adequate renal function: serum creatinine \< 1.5 mg/dL. At least 3 weeks since prior chemotherapy or cancer surgery (6 weeks for nitrosourea or mitomycin C).
- Normal cardiac function with no history of uncontrolled heart disease. Women subjects (if of child bearing potential and sexually active) and male subjects (if sexually active with a partner of child bearing potential) must use medically acceptable methods of birth control prior to study entry and for the duration of the study. Medically acceptable methods of contraception that may be used by the subject and/or his/her partner include abstinence, birth control pills or patches, diaphragm and spermicide, IUD, condom and vaginal spermicide, surgical sterilization, post menopausal, vasectomy, and progestin implant or injection.
- Written informed consent.
Exclusion
- Subject is pregnant or is breast feeding. Subject's life expectancy is less than 3 months. Subject exhibits confusion, disorientation, or has a history of major Psychiatric illness, which may potentially impair subject's understanding of the informed consent.
- Subject has signs and symptoms of acute infection requiring systemic therapy. Subject has used another investigational agent within 30 days of dosing with S CKD602.
- Subjects with known allergic reactions to camptothecin analogs, dextran sulfate or other components of S-CKD602 Symptomatic or uncontrolled brain leptomeningeal metastasis. CT scans are not required unless there is clinical suspicion of central nervous disease.
- Not recovered from reversible toxicity of prior therapy. Subjects with known brain metastases because of their poor prognosis because they often develop progressive neurologic dysfunction that would confound the evaluation of neurologic and other adverse events.
- Concurrent radiation therapy or radiation within 3 weeks of starting treatment with S-CKD602.
- Concurrent anti-neoplastic agents.
Key Trial Info
Start Date :
September 1 2003
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2006
Estimated Enrollment :
45 Patients enrolled
Trial Details
Trial ID
NCT00177281
Start Date
September 1 2003
End Date
May 1 2006
Last Update
December 19 2013
Active Locations (1)
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1
University of Pittsburgh Medical Center
Pittsburgh, Pennsylvania, United States, 15232