Status:
COMPLETED
Augmenting Antidepressant Treatment With Interpersonal Psychotherapy for Treating Late-life Depression
Lead Sponsor:
University of Pittsburgh
Collaborating Sponsors:
National Institute of Mental Health (NIMH)
Conditions:
Depression
Eligibility:
All Genders
60+ years
Phase:
PHASE4
Brief Summary
This study will determine whether adding interpersonal psychotherapy to treatment with the antidepressant escitalopram will be more effective in reducing symptoms of depression than antidepressant med...
Detailed Description
The purpose of this research study is to learn if adding psychotherapy (Interpersonal Psychotherapy) to antidepressant medication (escitalopram), will be more effective in reducing lingering symptoms ...
Eligibility Criteria
Inclusion
- Diagnosis of unipolar major depression
- Hamilton Rating Scale for Depression (HRSD) (17 item) score of 15 or higher
- Speaks English
- Willing to discontinue other psychotropic medications
- Availability of family member or other caregiver
- Hearing capacity adequate to respond to a raised conversational voice
Exclusion
- Lifetime diagnosis of bipolar disorder, schizophrenia, schizoaffective disorder, or any psychotic disorder
- Folstein Mini-Mental Status Exam (MMSE) of 17 or lower
- Suicidal
- History of treatment non-adherence in other Center protocols
- History of documented non-response to citalopram in other Center protocols
- History of non-tolerance to escitalopram therapy
Key Trial Info
Start Date :
April 1 2004
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2009
Estimated Enrollment :
319 Patients enrolled
Trial Details
Trial ID
NCT00177294
Start Date
April 1 2004
End Date
August 1 2009
Last Update
January 12 2012
Active Locations (1)
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1
University of Pittsburgh Medical Center
Pittsburgh, Pennsylvania, United States, 15213