Status:
COMPLETED
Serum Levels of Doxycycline at the Time of Abortion With Two Dosing Regimens
Lead Sponsor:
University of Pittsburgh
Conditions:
Abortion, Induced
Vomiting
Eligibility:
FEMALE
18+ years
Phase:
PHASE4
Brief Summary
This is a randomized double-blind, controlled trial comparing two regimens of pre-abortion doxycycline. The aims of the study are to determine the serum levels of doxycycline when administered pre-ope...
Detailed Description
This is a randomized double-blind, controlled trial comparing two regimens of pre-abortion doxycycline. The aims of the study are to determine the serum levels of doxycycline when administered pre-ope...
Eligibility Criteria
Inclusion
- Gestational age 15-23 weeks by ultrasound.
- Willing and able to sign an informed consent.
- Placement of cervical dilators. Dilators must be placed before giving any subject doxycycline in order to ensure that all subjects who receive doxycycline will have an abortion.
- Willing to comply with the study protocol.
- Age at enrollment of 18 years or more.
Exclusion
- Need for an urgent D \& E. Indications for this include ruptured membranes, advanced cervical dilation, infection, and fetal demise.
- Allergy to doxycycline or any tetracycline
- Exposure to or treatment for gonorrhea or chlamydia within the past 90 days.
- Current or recent (within the past week) use of any other antibiotic.
- Prior cardiac valve surgery or cardiac valve replacement. These patients should all receive alternative antibiotics for endocarditis prophylaxis.
- Active use of alcohol, heroin, or cocaine. Active use of alcohol will be defined as more than 2 drinks per day. Any use of heroin or cocaine will be considered exclusionary.
Key Trial Info
Start Date :
September 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2006
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT00177333
Start Date
September 1 2005
End Date
May 1 2006
Last Update
January 29 2016
Active Locations (1)
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1
Magee-Womens Hospital
Pittsburgh, Pennsylvania, United States, 15213