Status:
COMPLETED
Pharmacotherapy in Depression With Panic Spectrum
Lead Sponsor:
University of Pittsburgh
Conditions:
Major Depression
Eligibility:
All Genders
18-60 years
Phase:
PHASE4
Brief Summary
This research study is being conducted to find out if certain individuals benefit from taking medication for their depression with a low dose of the antidepressant medication Zoloft.
Detailed Description
Researchers at the University of Pittsburgh Medical Center Health System are currently recruiting men and women, ages 18 to 60, to examine the effectiveness of the FDA-approved medication sertraline (...
Eligibility Criteria
Inclusion
- Male or female ages 18-60;
- Current diagnosis of major depression, and a rating of ³15 on the HRS-D-25; - -Presence of significant, co-existing panic-agoraphobic spectrum symptoms,
- Absence of ongoing therapy with psychotropic medications (except for intermittent use of nonbenzodiazepine hypnotics) or willingness to be withdrawn from an ineffective ongoing antidepressant medications
- Physically healthy,
- Female participants of childbearing potential must be practicing a medically acceptable form of double-barrier birth control or using oral contraceptives such as birth control pills, implants, or injections;
Exclusion
- Females who are pregnant or breast-feeding;
- History of suicide attempt in the 6 months prior to entry, active suicidal ideation, or significant suicide risk;
- History of hypersensitivity to or current use of sertraline;
- Unstable or untreated medical conditions,
- Participants who do not wish to discontinue current, ineffective antidepressant treatment;
- Participants who have recently begun psychotherapy (less than 3 months prior to study entry);
- Diagnosis of current panic disorder, psychosis, substance or alcohol abuse, anorexia, bulimia, dissociative, bipolar disorder, or any other psychiatric or medical illness that would interfere with the best treatment strategy for the potential participant.
Key Trial Info
Start Date :
October 1 2001
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2007
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT00177996
Start Date
October 1 2001
End Date
January 1 2007
Last Update
January 15 2016
Active Locations (1)
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1
Western Psychiatric Insititue and Clinic
Pittsburgh, Pennsylvania, United States, 15213