Status:
COMPLETED
Determining Changes in Brain Structure Associated With Symptoms of Late-life Depression
Lead Sponsor:
University of Pittsburgh
Collaborating Sponsors:
National Institute of Mental Health (NIMH)
Conditions:
Late-Life Depression
Eligibility:
All Genders
55+ years
Brief Summary
This study will determine the changes in brain structure and function that are responsible for mood and cognition changes that are sometimes associated with late-life depression.
Detailed Description
The goal of this research study is to investigate the relationships among late-life depression (LLD), cognitive impairment and progressive neurodegeneration. The guiding hypothesis is that LLD patient...
Eligibility Criteria
Inclusion
- Diagnosis of a mood disorder
Exclusion
- Major acute medical illnesses or injuries known to have significant direct effects on cognitive functioning (e.g., metastatic cancer, multiple sclerosis, traumatic brain injury).
- Uncorrectable sensory handicap (e.g., blindness), because they are unable to complete the cognitive test battery.
- Exclusion criteria for MR scans include: cardiac pacemaker, aneurysm clip, cochlear implant, pregnancy, IUD, shrapnel, history of metal fragments in the eye, neurostimulators, weight of 250 lbs. or more, or claustrophobia.
Key Trial Info
Start Date :
August 1 2005
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
August 1 2011
Estimated Enrollment :
331 Patients enrolled
Trial Details
Trial ID
NCT00178087
Start Date
August 1 2005
End Date
August 1 2011
Last Update
April 7 2015
Active Locations (2)
Enter a location and click search to find clinical trials sorted by distance.
1
UPMC Late-Life Evaluation and Treatment Center
Pittsburgh, Pennsylvania, United States, 15213
2
UPMC Western Psychiatric Institute and Clinic
Pittsburgh, Pennsylvania, United States, 15213